I really think either way would look fine. I was just looking at our island to see what it looked like and we have a sink with a non-opening drawer and cabinets underneath it and then a drawer and cabinet on either side. We don't have any hardware on the faux drawer under the sink and I think I prefer it that way. Even though I normally like things very symmetrical and cohesive.
I don't have them in my house, and it's never really bothered me. Our vanities are pretty compact thought. My mom does have knobs and pulls on hers in the kitchens and baths. I think it makes more sense there b/c of the longer drawers.