I wear dailies, so this doesn't apply to me, but my husband just started. And he would have done it earlier but he uses the peroxide stuff, and until last month, I had never seen it generic.
That's what I use too--Clear Care. Target has been making a generic for a while, and I've used it but didn't love it. Clear Care has gone up in price recently and there have been less coupons, so I'll probably try the Up & Up again.
I didn't like the Target brand of Clear Care and neither did my H. So we switched back to the brand name. I find the Costco packages to be a better deal than buying at a grocery of drugstore.
I've always used Walmart brand but I went to the optometrist a few weeks ago and he said he doesn't recommend generic brands. He even offered to give me free samples whenever I needed solution if it was a cost thing. He'd rather give his free samples away instead of his patients buying generic. Apparently some of his patients have had issues with generic brands.
The optometrist my mom works for is the same. He will happily give out free bottles to his patients, if the alternative is using a generic solution. I wouldn't risk it, your eyes/eye health/eyesight is too precious.