What I call my ILs caused a big blow-up in the beginning of our marriage. I refuse to call them Mom and Dad (even my step-father, who essentially raised me, doesn't get called Dad) and I refuse to call them Mr. and Mrs. LastName because they are my ILs, not some folks I just met. As a result, I never address my FIL (MIL is now deceased) by any name or title.
For cards to both of us, like holiday cards, they sign Mom and Dad. I don't think I've ever noticed for my birthday cards, I think it's Mom and Dad Lastname.